Publications

Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation
Chandra*, A., Yoon*, S., Michieletto*, M.F., Goldman, N., Ferrari, E., Abedi, M., Johnson, I., Fasolino, M., Pham, K., Joannas, L., Kee, B., Henao-Mejia# J., and Vahedi#, G.
*co-first authors
#co-corresponding authors
Immunity
2023

Multiscale 3D genome organization underlies ILC2 ontogenesis and allergic airway inflammation
Michieletto* M.F., Tello-Cajiao* J.J., Mowel W.K., Chandra A., Yoon S., Joannas L., Clark, M.L., Jimenez M.T., Wright J.M., Lundgren, P., Williams A., Thaiss, C.A., Vahedi#, G., Henao-Mejia#, J.
*co-first authors
#co-corresponding authors
Nature Immunology
2022

TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors
Wang*, W., Chandra*, A., Goldman*, N., Yoon*, S., Ferrari*, E., Nguyen, S.C., Joyce, E.F., and Vahedi, G.
*co-first authors
Nature Immunology
2022

Topologically associating domains are disrupted by evolutionary genome rearrangements forming species-specific enhancer connections in mice and humans
Gilbertson SE, Walter HC, Gardner K, Wren SN, Vahedi G, Weinmann AS.
Cell Reports
2022

Stripenn detects architectural stripes from chromatin conformation data using computer vision
Yoon, S., Chandra, A. and Vahedi, G.
Nature Communications
2022

Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes
Fasolino M, Schwartz GW, Patil AR, Mongia A, Golson ML, Wang YJ, Morgan A, Liu C, Schug J, Liu J, Wu M, Traum D, Kondo A, May CL, Goldman N, Wang W, Feldman M, Moore JH, Japp AS, Betts MR; HPAP Consortium, Faryabi RB, Naji A, Kaestner KH, Vahedi G.
Nature Metabolism
2022

Transcription factors combine to paint the methylation landscape
Goldman, N., Chandra, A., and Vahedi, G.
Trends in Immunology
2021

BRD4 orchestrates genome folding to promote neural crest differentiation
Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R.
Nat Genet. 2021 Oct;53(10):1480-1492
2021

BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia
Kong W, Dimitri A, Wang W, Jung IY, Ott CJ, Fasolino M, Wang Y, Kulikovskaya I, Gupta M, Yoder T, DeNizio JE, Everett JK, Williams EF, Xu J, Scholler J, Reich TJ, Bhoj VG, Haines KM, Maus MV, Melenhorst JJ, Young RM, Jadlowsky JK, Marcucci KT, Bradner JE, Levine BL, Porter DL, Bushman FD, Kohli RM, June CH, Davis MM, Lacey SF, Vahedi G, Fraietta JA.
J Clin Invest. 2021 Aug 16;131(16)
2021

Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation
Abdel-Hakeem, M., Manne, S., Beltra, J.C., Stelekati, E., Chen, C., Nzingha, K., Ali, M., Johnson, J.L., Giles, J., Mathew, D., Greenplate, A., Vahedi, G., and Wherry, E.J.
Nature Immunology
2021