Publications

Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes

Fasolino, M., Schwartz, G.W., Golson, M.L., Wang, Y.J., Morgan, A., Chengyang Liu, C., Schug, J., Liu, J., Wu, M., Traum, D., Kondo, A., May, C.L., Goldman, N., Wang, W., the HPAP Consortium, Feldman, M., Moore, J.H., Japp, A.S., Betts, M.R., Faryabi, R.B., Naji, A., Kaestner, K.H., Vahedi, G.

Preprint biorxiv

2021

Exome-wide evaluation of rare coding variants

Park J, Lucas AM, Zhang X, Chaudhary K, Cho JH, Nadkarni G, Dobbyn A, Chittoor G, Josyula NS, Katz N, Breeyear JH, Ahmadmehrabi S, Drivas TG, Chavali VRM, Fasolino M, Sawada H, Daugherty A, Li Y, Zhang C, Bradford Y, Weaver J, Verma A, Judy RL, Kember RL, Overton JD, Reid JG, Ferreira MAR, Li AH, Baras A, LeMaire SA, Shen YH, Naji A, Kaestner KH, Vahedi G, Edwards TL, Chen J, Damrauer SM, Justice AE, Do R, Ritchie MD, Rader DJ.

Nature Medicine

2021

The Identity of Human Tissue-Emigrant CD8+ T Cells

Buggert, M., Vella,L.A., Nguyen, S., Wu, V., Sekine, T., Perez-Potti1, A., Maldini, C., Manne, S., Darko, S., Ransier, A., Kuri-Cervantes, L., Japp, A.S., Brody, I., Ivarsson, M., Hertwig, L., Antel, J.P., Johnson, M.E., Okoye, A, Picker, L., Vahedi, G., Sparrelid, E., Llewellyn-Lacey, S., Gostick, E, Björkström1, N., Bar-Or, A., Dori, Y., Naji, A., Canaday, D.H., Laufer, T.M, Wells, A., Price, D.A., Frank, I., Douek, D.C., Wherry, E.J, Itkin, M., Betts, M.R.

Cell

2020

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in beta Cells

Coate, K. C. ,Cha, J., Shrestha, S., Wang, W., Goncalves, L. M., Almaca, J., Kapp, M. E., Fasolino, M., Morgan, A., Dai, C., Saunders, D. C., Bottino, R., Aramandla, R., Jenkins, R., Stein, R., Kaestner, K. H., Vahedi, G., HPAP Consortium, Brissova, M., Powers, A. C.

Cell Metab

2020

Foxp3 Re-distributes Its Heavy Lifting

Chandra, A., Goldman, N., Vahedi, G.

Immunity

2020

Genetic Variation In Type 1 Diabetes Reconfigures The 3D Chromatin Organization Of T Cells And Alters Gene Expression

Fasolino M, Goldman N, Wang W, Cattau B, Zhou Y, Petrovic J, Link VM, Cote A, Chandra A, Silverman M, Joyce EF, Little SC; HPAP Consortium, Kaestner KH, Naji A, Raj A, Henao-Mejia J, Faryabi RB, Vahedi G.

Immunity

2020

Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels

Wang, W. , Fasolino, M., Cattau, B., Goldman, N., Kong, W., Frederick, M. A., McCright, S. J., Kiani, K., Fraietta, J. A., Vahedi, G.

PNAS

2020

TooManyCells identifies and visualizes relationships of single-cell clades

Schwartz, G. W., Zhou, Y., Petrovic, J., Fasolino, M., Xu, L., Shaffer, S. M., Pear, W. S., Vahedi, G., Faryabi, R. B.

Nature Methods

2020

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

Chen, Z., Ji, Z., Ngiow, S. F., Manne, S., Cai, Z., Huang, A. C., Johnson, J., Staupe, R. P., Bengsch, B., Xu, C., Yu, S., Kurachi, M., Herati, R. S., Vella, L. A., Baxter, A. E., Wu, J. E., Khan, O., Beltra, J. C., Giles, J. R., Stelekati, E., McLane, L. M., Lau, C. W., Yang, X., Berger, S. L., Vahedi, G., Ji, H., Wherry, E. J.

Immunity

2019