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TCF-1 Protein Plays Essential Role in Breaking Down Barriers as T Cells Form

New understanding of protein function also has implications for immunotherapies

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Penn Study Uncovers How Pancreatic Cells Reprogram Themselves to Limit the Immune Response in Patients at Risk for Type 1 Diabetes

Discovery by Penn Medicine researchers advances understanding of the underpinnings of the disease by creating a ‘map’ to chart pancreatic islet cells over time

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2021 Perelman School of Medicine Awards of Excellence

The following faculty members will receive this year’s Perelman School of Medicine Awards of Excellence. The distinguished awardees exemplify our profession’s highest values of scholarship, teaching, innovation, commitment to service, leadership, inclusion, and dedication to patient care. They epitomize the preeminence and impact we all strive to achieve. The awardees range from those at the beginning of their highly promising careers to those whose distinguished work has spanned decades.

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Discovery on Protein BRD4 Function in Mice Marks Critical Step in Research to Treat Patients with Complex Congenital Disorders and Cancers

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Vahedi lab joins the second phase of 4DN consortium!

Penn Medicine Researchers Receive Two Major NIH Grants for Studies of Genome Folding in Health and Disease

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Penn Medicine researcher receives early career honor from Burroughs Wellcome Fund

Penn Medicine researcher receives early career honor from Burroughs Wellcome Fund

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Penn Researchers Receive $1.05 Million Grant from Chan Zuckerberg Initiative

Penn Researchers Receive $1.05 Million Grant from Chan Zuckerberg Initiative

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DNA Misfolding in White Blood Cells Increases Risk For Type 1 Diabetes

New Penn Medicine study shows, in mice, that changes in DNA sequence may cause chromosomes to misfold in a way that elevates the risk for autoimmune diseases.

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“Icebreaker” Protein Opens Genome for T cell Development, Penn Researchers Find

Researchers describe the role of a transcription factor called TCF-1 in targeting the condensed chromatin and regulating the availability of genome sequences in T-cell development.

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“Back in Time”: Penn Researchers Unravel the Early Makings of an Exhausted T Cell

Penn Researchers Unravel the Early Makings of an Exhausted T Cell

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Media Coverage

The @vahedilab and Henao-Mejia laboratories present their latest preprint titled "A multi-enhancer hub at the Ets1 locus controls T cell differentiation and allergic
inflammation through 3D genome topology" https://www.biorxiv.org/content/10.1101/2022.10.28.514213v1

Super excited to share the collaborative work between @vahedilab and Henao-Mejia laboratories revealing the 3D genome organization of innate lymphoid cells. Congrats to everyone in particular Michael, John, Aditi, @ysora90, and Jorge https://www.nature.com/articles/s41590-022-01295-y

✨Take a look <Behind the paper> of the @vahedilab (@PennGenetics) offering an immunometabolism twist to the aphorism: “When you hear hoofbeats, think of horses, not zebras”, to uncover the so-called ‘cellular zebras’ of type 1 diabetes. #T1D #Immunology

https://healthcommunity.nature.com/posts/finding-cellular-zebras-in-type-1-diabetes-using-a-single-cell-multi-omics-approach?badge_id=nature-metabolism

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