Lab

Our laboratory is multidisciplinary, integrating cutting-edge computational and experimental approaches to develop a single to collective cell understanding of gene regulation and chromatin organization in immune cells.

Team Members

Aditi is a postdoctoral fellow in Vahedi Lab. Aditi received her PhD degree in Biochemistry, from University of Calcutta, India. During her PhD work at Indian Statistical Institute (Supervisor: Dr. Raghunath Chatterjee, PhD), she studied the effect of genetic variations and DNA methylation changes in Psoriasis, an autoimmune skin disease. Her research interests include understanding the genomic factors regulating immune cells in human diseases. As a postdoc in Vahedi Lab, her work focuses on studying 3D chromatin conformation and gene regulation in Type1 Diabetes.

Aditi Chandra, PhD

Postdoctoral fellow

Naomi is a student in the Immunology Graduate Group. Naomi received a B.S. in Biology from Rider University in 2014. During her undergraduate, she did research on the tumor micro-environments suppressive effects on T and B cell activation. Her ongoing graduate research in the Vahedi Lab seeks to understand the mechanisms through which T cell specific transcription factors establish the enhancer landscape during development.

Naomi Goldman

PhD student

Golnaz Vahedi, a native of Iran, is currently an Associate Professor of Genetics (with tenure) at the Perelman School of Medicine, University of Pennsylvania. Golnaz, whose first name is pronounced as gol’naaz, studied Electrical Engineering at Sharif University of Technology in Iran. Sharif University is known for its large number of elite alumni who join the academic world, including the late Maryam Mirzakhani, the first female mathematician to be awarded a Fields Medal. Golnaz received her Ph.D. with Drs. Edward Dougherty and Jean-Francois Chamberland in Electrical Engineering at Texas A&M University. She then joined the laboratory of Dr. John O’Shea at the NIH as a postdoctoral fellow to study the epigenomic regulation of T cells. It was in the O’Shea lab that she found studying the epigenome is similar to dissecting electrical circuits. As an independent investigator, she uses systems-based approaches to understand molecular details of gene regulation in the immune system. She is the recipient of a number of awards including the NIH Director’s Award (twice), NIAID K22 Career Transition Award (perfect score), Alfred P. Sloan Fellowship, Chan Zuckerberg Initiative Award, W. W. Smith Charitable Trust, Burroughs Wellcome Fund, and Michael S. Brown New Investigator Research Award. She serves on the advisory boards of Cell Press journal Immunity and Science Immunology.

Golnaz Vahedi, PhD

Principle Investigator vahedi@upenn.edu

Sora is a postdoctoral fellow in Vahedi Lab. She received her Ph.D in biological sciences from UNIST in South Korea (Advisor: Dougu Nam, Ph.D). During her Ph.D, she focused on developing tools for pathway and/or network analysis of genomic and transcriptomic data. She joined Vahedi lab to extend her sight to epigenetic regulation of gene expression. As a postdoc, she is working on developing tools finding architectural stripes in cells from various 3D genomic data. In addition, she is interested in unveiling the secret of stripes. What does it look like? How is it formed? What are the characteristics of it? and what are the roles of it in our cells? Her goal is to solve these problems one by one and discover the cause of diseases in the perspective of 3D structure of the genome.

Sora Yoon, PhD

Postdoctoral fellow

Abhijeet completed his bachelor’s in Computer Science & Engineering and master’s in Bioinformatics from India. He received his Ph.D. training with Drs. Ming-Ying Leung, Sourav Roy, and Dr. Sangjin Kim in Computational Science at UTEP. His Ph.D. research focused on development and application of machine learning algorithms to analyze high-throughput biological data including microarray, DNA methylation, and RNA-seq data. His current research interests include the application of statistical machine learning methods and computational models on single-cell genomics. His goal as a Postdoc is to gain biological insights from multi-omics and 3D genomic data through computational techniques.

Abhijeet R Patil, PhD

Postdoctoral fellow

Emily is a research specialist and lab manager in the labs of Dr. Golnaz Vahedi and Dr. Robert Babak Faryabi. Emily received a B.A. in Biology from Swarthmore College in 2019. During her undergraduate study, she conducted research on long non-coding RNAs in human cells and their role in cancer progression. After graduating, she worked in the lab of Dr. Veronique Lefebvre at the Children’s Hospital of Philadelphia on modeling Lamb-Shaffer Syndrome in mice. She plans to pursue a Master’s degree in Human Genetics sit for certification to become a Genetic Counselor.

Emily Ferrari

Lab manager

Maryam is a postdoctoral fellow in Vahedi Lab. She received her PhD in Medical Genetics from Isfahan University of Medical Sciences. During her PhD, she employed a combination of experimental and computational approaches to construct a multi-layer network in diabetic kidney disease and introduced some potential drug targets for this complex disease. As a postdoc, she is interested in exploring the role of T-cells in type 1 diabetes pathogenesis using single-cell multiome ATAC + gene expression. Her goal is to gain a better understanding of the mechanisms underlying the development of type 1 diabetes by applying a holistic and systematic approach.

Maryam Abedi

Postdoctoral fellow

Ed is a research specialist in Vahedi Lab. He received a B.S. in Mathematics from Yale University in 2020. During his undergraduate study, he conducted research modeling heart muscle contraction and studying spectral properties of graphs. He hopes to pursue a PhD in computational biology or a related field.

Ed Gelernt

Research Specialist

Izzy is a research specialist in the Vahedi lab. Izzy received a B.A in biology with a biochemistry concentration from Haverford College in 2022. During her undergraduate degree, she conducted research on the RNA binding protein, YBX3, and investigated the molecular mechanism behind its regulatory abilities. She plans to pursue a PhD in biochemistry and continue to expand her knowledge of biochemical processes in the human body. In her free time, Izzy enjoys playing squash and taking care of her aquarium.

Izzy Johnson

Research Specialist A

Carlos is an NIH PREP scholar in the Vahedi Lab. He completed his B.S. in Biology from Winthrop University in 2022. During his undergraduate career, one of his projects involved using scRNA-seq data to map the lower respiratory tracts of influenza infected mice and of SARS-CoV-2 infected patients utilizing alveolar lavage samples. Carlos will be conducting a 1-2 year research project in lab, afterwards he plans to pursue a Ph.D. in Immunology.

Carlos Escoto-Diaz

NIH PREP scholar

Affiliations

Funding Sources

Bethesda, MD

San Francisco, CA

Bethesda, MD

Bethesda, MD

Research Triangle Park, NC

Join

If you are interested in these opportunities,
send an email with your CV to vahedilab.jobs@gmail.com